Overview

PMC Isochem has developed over 40 years a first class technology platform offering to our customers a competitive development and manufacturing cGMP service with a strong position in hazardous chemistry. ​

 Your benefits from PMC Isochem’s offer ​​

  • Chemistry and process expertise​

  • Large scale multi-step synthesis ​

  • Handling large volumes of hazardous materials​

  • Large scale HSE risk management track-records​

  • Reliable and competitive solution​​

Non exhaustive technology overview ​​

  • Alkylation: Methyl iodide, dimethyl sulfate, various alkylating agents​

  • Amino acid chemistry: protection, activation, coupling, synthesis of unnatural amino acid

  • Biocatalysis, enzymatic catalysis  ​

  • Catalysis: Lewis acids  (Titanium tetrachloride, aluminium trichloride, boron trifluoride, …), homogenous and heterogenous catalysis (metal and non metal catalysts)​

  • Cyanide chemistry: Sodium cyanide and the like, acetone cyanohydrin​

  • Cryogenic chemistry: Organometallic (Li, Mg, ..) and asymmetric synthesis​

  • Halogenation: chlorine, bromine, iodine and others halogenation reagents …​

  • Hydrogenation: hydrogen up to 40 bar​

  • Nucleophilic bromination: Phosphorus oxybromide, phosphorus bromide, …​

  • Nucleophilic chlorination: Thionyl chloride, sulfuryl chloride, phosphorus oxychloride, phosgene, …​

  • Nitration: 100% nitric acid, sulfonitric acid, …​

  • Nitrosation: Sodium nitrite, alkyl nitrite

  • Sulfonation: Chlorosulfonic acid, 20% sulfuric oleum, Pyridine/sulfur trioxide, …​

  • Ring Opening Polymerization ( ROP ) of amino acids n-carboxyanhydride (NCA) for polyamino acids synthesis like (Poly-Sarcosine, Poly-L-Lysine, Poly-Glutamic acid, Poly-L-Leucine, Poly-D-Leucine, Poly-Aspartic acid, and many others 

  • Reduction: Sodium borohydride and the like, Red-Al, in situ generation of diborane, activated borohydrides (with LiCl, ZnCl2), lithium aluminium hydride, hydrazine hydrate​

  • Oxydation: Hydrogen peroxide, sodium chlorite, sodium hypochlorite, chlorine, …​

  • Organometallic Chemistry: Butyl lithium and the like, lithium diisopropylamide, sodium hydride, sodium and potassium alcoholates, metals (magnesium, zinc, …)​

  • Phosgenation: Phosgene and phosgene substitute​

  • Specific equipment: Distillation and crystallization/drying of highly corrosive chemicals​

  • Miscellaneous: hydroxylamine sulfate or hydrochloride, silicium derivatives, boron derivatives, strong acids​

Flow chemistry and Continuous process

PMC Isochem invests in R&D for continuous flow reaction technology in Partenship with Orleans (France) University - CNRS, ICOA, UMR 7311 and ICARE Laboratories

 

 

 

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