PMC Isochem has developed over 40 years a first class technology platform offering to our customers a competitive development and manufacturing cGMP service with a strong position in hazardous chemistry.
Your benefits from PMC Isochem’s offer
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Chemistry and process expertise
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Large scale multi-step synthesis
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Handling large volumes of hazardous materials
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Large scale HSE risk management track-records
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Reliable and competitive solution
Non exhaustive technology overview
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Alkylation: Methyl iodide, dimethyl sulfate, various alkylating agents
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Amino acid chemistry: protection, activation, coupling, synthesis of unnatural amino acid
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Biocatalysis, enzymatic catalysis
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Catalysis: Lewis acids (Titanium tetrachloride, aluminium trichloride, boron trifluoride, …), homogenous and heterogenous catalysis (metal and non metal catalysts)
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Cyanide chemistry: Sodium cyanide and the like, acetone cyanohydrin
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Cryogenic chemistry: Organometallic (Li, Mg, ..) and asymmetric synthesis
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Halogenation: chlorine, bromine, iodine and others halogenation reagents …
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Hydrogenation: hydrogen up to 40 bar
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Nucleophilic bromination: Phosphorus oxybromide, phosphorus bromide, …
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Nucleophilic chlorination: Thionyl chloride, sulfuryl chloride, phosphorus oxychloride, phosgene, …
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Nitration: 100% nitric acid, sulfonitric acid, …
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Nitrosation: Sodium nitrite, alkyl nitrite
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Sulfonation: Chlorosulfonic acid, 20% sulfuric oleum, Pyridine/sulfur trioxide, …
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Ring Opening Polymerization ( ROP ) of amino acids n-carboxyanhydride (NCA) for polyamino acids synthesis like (Poly-Sarcosine, Poly-L-Lysine, Poly-Glutamic acid, Poly-L-Leucine, Poly-D-Leucine, Poly-Aspartic acid, and many others
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Reduction: Sodium borohydride and the like, Red-Al, in situ generation of diborane, activated borohydrides (with LiCl, ZnCl2), lithium aluminium hydride, hydrazine hydrate
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Oxydation: Hydrogen peroxide, sodium chlorite, sodium hypochlorite, chlorine, …
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Organometallic Chemistry: Butyl lithium and the like, lithium diisopropylamide, sodium hydride, sodium and potassium alcoholates, metals (magnesium, zinc, …)
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Phosgenation: Phosgene and phosgene substitute
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Specific equipment: Distillation and crystallization/drying of highly corrosive chemicals
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Miscellaneous: hydroxylamine sulfate or hydrochloride, silicium derivatives, boron derivatives, strong acids
Flow chemistry and Continuous process
PMC Isochem invests in R&D for continuous flow reaction technology in Partenship with Orleans (France) University - CNRS, ICOA, UMR 7311 and ICARE Laboratories