Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as:
- solubilizer of poorly soluble drugs
- absorption enhancer
- stabilizer of Amorphous Solid Dispersion (ASD)
- vehicle for lipid-based drug formulation
Vitamin E TPGS is also used as an efficient source of natural Vitamin E both for therapeutic and nutrition purposes.
A National Formulary (NF) monograph is in the United States Pharmacopeia / National Formulary (USP/NF) version USP 40 – NF 35. Several commercial drugs using Vitamin E TPGS are approved by FDA and EMEA, PMDA.
Vitamin E TPGS in drug formulation
Two anti HIV drugs, AGENERASE® (Amprenavir) soft gel capsules and oral solution and APTIVUS® (Tripanavir) oral solution
One anti HCV drug, VIEKERA Pack™ (combination of 3 APIs) tablets
PMC Isochem’s offer
PMC Isochem his producing, under GMP, ISODEL® Vitamin E TPGS for 10 years. PMC Isochem owns a DMF Type II
technical support for storage and handling
information for quality and pharmaceutical regulatory